
When you breed dogs of different sizes, the male should always be the smaller dog, actually. A 50-pound bitch having a 20-pound male’s puppies is gonna go smoothly, a 20-pound bitch having a 50-pound male’s puppies is likely to die in the birth because the puppies are too big. So if you wanted a litter of Mini Labradoodles, for example, you’d have a male miniature poodle get it on with the larger female labrador.