It depends on what preexisting conditions there are and the dosage. THC isn't always high risk for neurodivergent people. I have never, ever had a "manic" issue or have even greened out in my 3 years of consuming THC products. The key is to start as small as possible (aka the lower end dosage recommended for your height/weight) and work up bit by bit. Do your research, be responsible, don't be head on, and you'll be fine