The constitution is not scripture or the bible. Our founding fathers knew that the system they made was imperfect and so they gave us the ability to change our constitution by vote of the people. There’s nothing wrong with disagreeing with the constitution. In fact you could say by disagreeing with the constitution you’re doing exactly as our founding fathers intended.
If rights were only ‘given by nature,’ we wouldn’t have needed amendments to end slavery or give women the vote. Our rights have meaning because we define and protect them through law, not because they’re frozen in time. These rights only have meaning because we defend and protect them through the rule of law.